I hav been dealing with chronic pain since 2008. I have severe degenerative disc disease and severe osteoarthritis. My feet are beginning to get deformed and I am very limited to what kind of shoes I wear. My neck is a mess, my spine and my shin pain adds to my condition. This tumeric has made a huge difference in my nights sleep plus my daily pain. I have friends that are having success with it also. Don't let the price scare you away if you can afford it. I recommend anyone start off with 6 daily the first 3 or 4 days then level off to 4 a day, 2 twice daily. I can take them with or without food. I am sure without food would make them more bioavailable. I go off of them 2 or 3 days and my pain increases. I try not to let myself run out. If you are suffering with chronic pain I hope this helps you as much as it has me. UPDATE ️I have been taking this supplement well over a year. It is the best thing I have ever used to help with my severe arthritic pain. I have talked with the companies representatives. They informed me it is being used for cancer pain with good results. The best information I received on the phone call was if the consumer stops taking it every 6 weeks for 2 to 3 days then resumes their dosage it will reboot the effectiveness. I do it for that reason only. When I do it it is hard because my pain is so bad on those days it shocks me into reality just how much this has done for me. It rids me of probably 75% of my pain. I am so thankful. It is comforting to know I am not taking toxic drugs with bad side effects. For this I am grateful.